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Short and Long term Effects of Conflicts on Healtcare

October 30, 2021 12:26 pm


The health of the society is the collective sum of the individual health of its population; physical and mental health are equally important in overall well-being (Kindig & Stoddart, 2003). A conflict causes significant destruction of life and property. For those who survive the initial assault, individually and collectively, the outlook for short and long-term physical and mental health is multifactorial and regretfully grave. Regardless of the state of an individual’s health and the healthcare delivery system, a conflict is a significant added burden that most middle- and low-income countries can afford the least (Jacob, 2009; Mills, 2014). Armed conflict has become a global health issue that has led to casualties and injuries, disrupted public health systems and social cohesion, and created displacement, poverty, and unemployment, all having long-term consequences that are also intergenerational (Samman E et al., 2018). In most low- and middle-income countries, the health care systems are grossly underfunded, relatively frequently underdeveloped, and ill-equipped to respond to the added stress caused by a conflict (Orach, 2009). The limitation of capacity in the health care delivery system is unsurmountable since most of those displaced are internally displaced in a conflict zone or to a neighboring county (Murshidi et al., 2013). The recipient countries of the refugees are more likely to be of the same low- or middle-income country level (Huang C & Graham J, 2018). The impact on the health care systems goes far beyond the conflict zone and affects the entire population dependent on the fragile system (Johnson, 2017). The short-term effects may be apparent in the destruction of the facilities and displacement of the healthcare workers. The long-term impact may be more subtle and multifactorial. Lack of resources (supply and personal) (Brundtland, 2000) and inadequate recognition and response to the stress on the health care staff (Finnegan et al., 2016) results in a downward spiral of access to care and quality of care in a conflict zone. The short-term physical injuries, the disabilities that follow, and the long-term effect of the psychological impact of a conflict burden the subset of the ill-equipped society in the middle- or low-income countries (Garry & Checchi, 2020). Women, children, the elderly, disabled, and injured require protection, care, and support where its least available (Jahanshahi et al., 2020; Macksoud & Aber, 1996). Moreover, the traumas caused by conflict on the children are long-lasting and may span to adulthood with lifelong consequences in their education, earning potential, social integration, and ultimately their health (Kaminer et al., 2016).

The different variables of conflict and health determinants, short and long-term, will be discussed with examples. Finally, the specific conflict of Nagorno-Karabakh will be discussed.


Health was initially defined by WHO in 1946 as “…a state of complete physical, mental and social well-being, not merely an absence of disease or infirmity.” However, this definition has been a subject to evolving interpretation by many in different disciplines (Brüssow, 2013; Huber et al., 2011). Therefore, we will consider a broad definition of health as physical, mental, and social well-being encompassing the broader health determinants (Dahlgren G & Whitehead M, 1991).

Conflicts result in death and destruction and should be considered a public health problem affecting individuals in the conflict zone (C. J. L. Murray et al., 2002, 2016).

The short- and long-term effects of the conflict will be discussed at the individual and population levels. It is essential to acknowledge that the descriptive nature of the term “short” and “long term” is vague in this setting. Unlike specific medical disciplines, there is no clear definition for the transition between the two time frames.

Short term impact of Conflict on Individual and Population health:

Individual and population health are intricately intertwined; it is a continuous spectrum where collective individual health becomes population health (Ashraf et al., 2009; Bauer, 2019; German & Latkin, 2012). Individual health is discussed in the context of an individual’s medical care, whereas population health is in public health setting (Arah, 2009). All health determinants affecting individual health will have implications on the population’s health. An individual’s health is determined by several variables, including physical health, employment, shelter, social and family structure. A conflict will have a broad short-term implication on individual health, whereas population health effects present long-term symptoms (Figure 1)[1].

An individual in any health status will have 1-Preventive (vaccination, screening mammography or colonoscopy, well-child checkup, pre-natal) or 2-Therapeutic (treatment for NCD’s, injuries due to motor vehicle accidents, sports injury, mental health, STD’s, substance dependence) healthcare requirements (Doocy et al., 2015; Pavli & Maltezou, 2017). Limited data and follow-up have shown that the pre-conflict health delivery infrastructure will determine the level of care that can be delivered post-conflict at an individual level, with implications for the population at large (Afzal & Jafar, 2019). The same is true for other determinants of health, where the pre-conflict level will predict the post-conflict state (Spiegel et al., 2010). Significant attention is given to the immediate care needed in a conflict zone. Research has shown that psychological distress, preexisting NCD’s, reduced physical activity, change in the living arrangements leading to smoking and alcohol use, violence and insecurity in refugee camps, and discriminations in host countries all have long term effects that receive much less if any attention (B. Roberts et al., 2012).

The outcome of physical injury, direct (penetrating, non-penetrating) or indirect (building collapse) because of a conflict, will depend on the existing infrastructure. Military capabilities aside, a rocket launch from Occupied Palestinian Territory (oPt) to Israel has a much different outcome than a counterattack from Israel to Gaza. The disparity between the preexisting health of these two neighboring populations has been described (Rosenthal, 2021). However, the outcome of the inflicted attack may be as much a function of a superior robust trauma system in Israel and lack thereof the same in oPt (Borgohain & Khonglah, 2013). The psychological impact on the long-standing conflict between Israel and oPt has also been documented (Rosenthal, 2021). The poor socio-economic condition at the oPt is reflected in the higher Standardized Mortality Rate (SMR) for the population at oPt compared to Israel for most of the NCD (Rosenthal, 2021).  The higher SMR is an example of how poor individual health in a conflict zone translated to poor population health. The distinction between short-term and long-term health is difficult to distinguish; however, the long-term effect on children is documented (Jürges et al., 2020).

An employed individual with family housing, adequate nutrition, sanitation, clean water, a school for children, and safe living condition free of violence may be able to withstand the short-term insult of a conflict; however, the long-term outcome in the context of psychological, safety, and security (food, education, physical, family) is much less predictable (Afzal & Jafar, 2019).

An individual may suffer an injury during a conflict. The physical injury may result in disabilities that will translate to long-term disabilities. The psychosocial, economic, and physical consequences may be life ling not only affecting the injured but also the family at large. An initial injury requires significant resources for treatment in the form of supply, personal, and logistics. However, very little is invested in the long-term effect of an acute injury, both the physical and mental (post-traumatic stress disorder, PTSD). The unique nature of the injury may also present specific challenges for short- and long-term treatment options. Chemical and biological weapons (barred by international norms) require highly specialized settings to avoid healthcare exposure and care. In many conflict-affected regions, women and children bear the shortest- and long-term impact of conflict (Bendavid et al., 2021; Murthy & Lakshminarayana, 2006), as they tend to lack access to maternal and child health (MCH) services, vaccination services, face malnutrition, and various forms of exploitation such as rape gender-based violence, and discrimination. The health providers allocate the available medical resources towards those suffering from severe injuries, leading to de-prioritizing MCH services, which risks poor health outcomes that may have short-term and long-term consequences (Devakumar et al., 2015). Regions facing conflict usually have higher neonatal morbidity and mortality rates because of poor nutrition, lack of access to adequate healthcare, maternal stress, and reduced breastfeeding rates (Sapir, 1993). Syrian women, for example, used to enjoy access to standard antenatal care during pre-conflict periods, and close to 96% of birth deliveries were usually with the assistance of a skilled midwife (Kherallah et al., 2012; Samari, 2017). However, this has changed post-conflict, with many having higher rates of poor outcomes from pregnancy, including low birth weights, an increase in fetal mortality, antenatal complications, and occurrences of premature labor (Samari, 2017).  The effect of poor pre-and post-natal health of a child may have dire consequences which will impact all aspects of the individual and population life short and long term. These individual short-term health outcomes resulting from a conflict have broad-reaching short- and long-term effects on the individual, society, and population.

The loss of life of young men has a long-term detrimental outcome for the surviving family. The population in a conflict zone may also be directly involved in the injuries caused by bullets, shrapnel, bombing, resulting in collapse buildings and Chemical weapons. Secondary injuries may include non-recoverable injuries due to severity or lack of adequate and effective healthcare personnel to treat the injuries. Destruction of healthcare facilities, housing infrastructure all contributes to delayed health delivery. Secondary injuries in the form of water pollution possibly result in communicable diseases, malnutrition due to lack of food, and breakdown of the infrastructure roads and bridges to access the food. Immediate psychological injuries, including post-traumatic stress disorder, can have short and long lifelong consequences (Hynie, 2017). The same is true of those who have been internally displaced within the same social and cultural environment (B. Roberts et al., 2009). As conflicts persist, the health care spending decreases as the military spending raises, further hindering the population health care (Fan et al., 2018). The allocation of the resources results in further draining of the health care infrastructure.


Most of the Conflicts in the world are carried over in the middle to low-income countries (Vestby et al., 2021). The healthcare burden in those countries includes infectious communicable and non-communicable diseases. Lack of reliable water sources, poor sanitation, poor education, and social safety networks and housing are additional contributors to the health caused by the destruction caused by conflicts. Most middle- to low-income countries have a population with a premature death rate and lower life expectancy (Ho & Hendi, 2018; Islam et al., 2018) compared to high-income countries. Most conflict involves primarily young and middle-aged men who may succumb to direct injuries.

Causes of conflicts are multifactorial. The incidence of conflicts has been rising since 1950. Economic and social inequalities, food insecurity, educational and health inequities, poverty, political, cultural, religious, and ethnic frictions are contributing causes for conflicts (Burns & Devillé, 2017; Džuverovic, 2013; Lichbach, 1989). Since the 1950s, there have been more intense conflicts within and amongst countries (Stewart, 2002). The additional distressing statistic is that nearly 80-90% of the victims of the conflicts are now civilians. This figure includes those directly killed or injured in the conflict and those who succumb to the indirect effects of the conflict, including infectious diseases, NCD (due to lack of adequate medical care), malnutrition both as refugees and IDP’s (A. Roberts, 2010). Quite commonly, a vicious cycle of conflict is formed intergenerationally (Devakumar et al., 2014). As a result, the population and society get entrapped in a loop of continued conflict. The inability to escape the cycle of conflict and violence is due to the failure to resolve and break away from the underlying causes (Mitchell, 2019). A conflict breaks the root cause of the causes of social determents of health, some noticed in a concise time frame and most reflected, at times an unnoticed long term (Braverman & Gottlieb, 2014).

Case Discussion: Armenia, The Nagorno-Karabakh Conflict.

Nagorno-Karabakh (NK) is a predominantly Armenian community that Armenia and Azerbaijan have governed since early 1900. Armenia became independent in 1991 with the fall of the Soviet Union. Armenia inherited a centralized health care system underfunded, understaffed, and highly specialized state-run district hospitals (Hovhannisyan, 2004; Torosyan et al., 2008a). Since early 2000, it has been undergoing a slow transition, emphasizing preventive primary medical care and less inpatient centralized hospitalization. There has been a steady transition toward a form of universal health care with a private out-of-pocket (OOP) model (Chukwuma et al., 2021). Health Systems in Transition (HiT) is a slow and complicated process to implement (Erica Richardson, 2013). As part of the health care delivery system in Armenia, these changes have been perceived negatively by the citizens of Armenia (Harutyunyan & Hayrumyan, 2020). The individual’s lack of trust in the health care system may have been a critical issue to the addition of the conflict and the start of the COVID-19 pandemic. The first case of Covid was reported officially in Armenia on February 29, 2020 (Reuter Staff, 2020).

Pre Covid (March 11, 2020) and before the onset of the Conflict (September 27, 2020) in NK and Azerbaijani invasion, the health care system was somewhat functioning as an OOP model, with obstetrical and pediatric care entirely funded by the central government (Erica Richardson, 2013). The conflict resulted in between 90,000 to 120,000 ethnically Armenian from NK to Armenia (Connelly A, 2020). With the massive influx of refugees to Armenia, the social, educational, community, and health services were overwhelmed. Availability of social services, housing, nutritional support, preventive care was strained with little buffer available in the system. The displaced refugees from NK to Armenia had significant preexisting health care needs, probably due to inadequate preventive and primary care access in NK (Project HOPE, 2020).

The immediate short-term healthcare needs of the NK residents escalated as the hospitals became a target of the bombing and rocket attacks in violation of international norms (Hugh Williamson, 2021).

When the focus in Armenia was the care of displaced Armenians from NK, caring for the injured, and providing supportive services to the displaced and disabled, COVID-19 was not seen or be considered a priority (Balalian et al., 2021). The conflict added complexity to culture and society, skeptical of the preventive measures against COVID-19 and vaccination efforts (Badalyan et al., 2021). The skeptical public was only reinforced with false information propagated by media supported by the US government (Tatev Hovhannisyan, 2020). The skepticism against COVID-19 contrasts with the very high vaccination rate for other childhood infections as tracked (WHO-Europe, 2019). Overburdening of the system is an example of how a fragile society, in a LIC, has little capacity to absorb the insult of a conflict. Before the Conflict, Armenia faced much public health, political, economic, and international relations challenges. Systemic changes initiated by the Armenian Ministry of Health (MOH) in the late 1990s resulted in some index health quality measured show improvement; however, the health indicators had not developed at the desired pace predicted (Torosyan et al., 2008b). In the health sector, NCD, smoking, rural poverty, and unemployment contribute to poor predictive outcomes of population health (S. Murray, 2006; Nowack, 1991). The short- and long-term health implications of the NK conflict directly affected those involved and the host for the refugees (United Nations Office for the Coordination of Humanitarian Affairs, 2020). Short- and long-term psychological trauma of the conflict and the stress of displacement, lack of employment, and the long-term uncertainty for children, superimposed on the ongoing COVID-19 pandemic, should not be overlooked by the host community (Markosian, Khachadourian, et al., 2021; Markosian, Layne, et al., 2021). The unresolved stress of displacement, long-term, can exacerbate the risk of poor health for women, children, and the elderly due to violence (Bradley, 2018).

The World bank changes its classification for the income grouping of the countries in 2018 (World Bank Data Team, 2018). Initially listed as  Low–To middle-income country, Armenia was reclassified and Upper–Middle-income country (World Bank, 2018). The change in the income level classification is reflective of an expanding economy in transition. The long-term effect of the conflict on the population is the indirect result of the economic loss experienced. International Monetary fund projects a -7.25% contraction in GDP due to the combination of the conflict, the influx of refugees, and the second surge of the Covid-19. The significant contraction of the economic activity is due mainly to the loss of tourism and travel of Armenian in diaspora in 2021-2022 (IMF Staff, 2020). The reduced income will significantly impact government spending and the allocation of the fund in the healthcare system.

The cultural barriers to care should also be emphasized. The long-term mental health concerns for the displaced, injured, and disabled would need to be dealt with (Soghoyan et al., 2009). As with most eastern cultures, mental health and psychological disorders are frequently minimized, underdiagnosed, and inadequately treated due to stigmatization by society (van Baelen et al., 2005). This dismissive approach may translate to policy, funding, and treatment policies that can hinder the individual and consequently population health. The inability to procure and maintain gainful employment and provide for one’s family due to untreated mental illness will result in poor health outcomes secondary to decreased earning potential, inability to maintain employment or cope with the stress (Khalema & Shankar, 2014).


Conflicts, regardless of the underlying cause, affect the fiber of society. Education, employment, and family functions may be disrupted. In addition, housing loss, inadequate food, and sanitation are experienced by most in the zone of conflict, and healthcare delivery is interrupted. Insomnia, fear fatigue may set in quite quickly. These short-term effects will have long-term consequences individually and the population at large.

At an individual level, in addition to the potential direct injury (penetrating, non-penetrating crush, biologic and chemical, falling debris, shrapnel wounds, burn, broken bones), communicable and non-communicable disease (preexisting, undiagnosed) need to be addressed.  The initial injury may lead to permanent physical disfigurement, loss of limb and function. In addition, mental health deterioration is seen quite frequently, presenting as insomnia, a sense of despair, and anger. As time progresses, even with improvement or resolution of some of the physical injuries, post-traumatic stress disorder (PTSD) and depression are examples of mental health conditions that set in.

At a population level, the initial injury is the destruction of infrastructure, population displacement, economic activity collapse, and social services. Then, as with the progression of the conflicts, the elements of a functioning society break down, including the health care delivery system.

Health care determinants are all affected in a conflict to varying degrees, whether short or long term, at individual or population level.


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van Baelen, L., Theocharopoulos, Y., & Hargreaves, S. (2005). Mental health problems in Armenia: Low demand, high needs. British Journal of General Practice.

Vestby, J., Buhaug, H., & von Uexkull, N. (2021). Why do some poor countries see armed conflict while others do not? A dual sector approach. World Development, 138, 105273.

WHO-Europe. (2019). Routine immunization profile Armenia. Retrieved from

World Bank. (2018). World Bank Country and Lending Groups. Retrieved August 22, 2021, from

World Bank Data Team. (2018, July 1). New country classifications by income level: 2018-2019. Retrieved August 22, 2021, from


[1] Transition from individual to population with parallel short to long term effect. The individual health impact will persist for individuals’ long term, however the collective effect on population occurs long term.

Covid 19:Anesthesia, Weight Loss Surgery and Malnutrition

October 30, 2021 8:52 am

As the COVID-19 pandemic is charting its course into 2022,  as health care providers, we have had to adapt and adjust to the transient and shifting environment. Testing for COVID-19 has been in place, and is now part of the standard for preoperative work-up. In addition, covid testing will likely be part of screening any surgical procedure for the foreseeable future.

The challenge of pandemic control is the large pockets of populations in the US and worldwide that do not have protection against the virus and are not vaccinated. Vaccination provides the only proven long-term protection against COVID-19 infection and its long-term persistent health effect. In addition, the complication rate reported in scientific journals is negligible compared to the complication and death rate from the COVID-19 infection.

There are implications of covid infection and general anesthesia published in peer-reviewed journals. The increased risk of general anesthesia after covid infection is related to the severity of the initial infection and the extent of the treatment required, and the persistence of the post covid symptoms, including shortness of breath, fatigue, and laboratory finding elevated inflammatory markers. Long after resolution of the acute COVID-19 symptoms, the most common persistent complaints are fatigue, shortness of breath, Joint and chest pain; and all these increase the risk of post-operative complications (Carfì et al., 2020)

The required delay for surgery may be as short as 2-4 weeks to as long as six months or longer if the persistent symptoms are present. Surgery may not be avoidable in a critical life-threatening situation and may be necessary even with a much-increased risk of complication (Collaborative, 2020). Recovery post-COVID-19 may not be complete with the resolution of the initial symptoms (Dexter et al., 2020)

Recent publications and scientific presentations have also shown the protection that weight loss surgery and maintained weight loss provide in those who come down with the COVID-19 infection (Aminian et al., 2021). However, the rate of weight gain, lack of weight loss is worse for weight loss surgical patients post COVID-19 disorder (Bullard et al., 2021; Conceição et al., 2021). Furthermore, patients with COVID-19 infection post weight loss are at a higher risk of malnutrition (di Filippo et al., 2021; Kikutani et al., 2021). Up to 40% of patients have malnutrition if hospitalized with COVID (Anker et al., 2021).

To summarize, Weight loss and weight loss surgery reduce the severity of the initial COVID-19 infection. However, it increases malnutrition risk, requiring nutritional support and surgical interventions in non-responsive cases.



Aminian, A., Fathalizadeh, A., Tu, C., Butsch, W. S., Pantalone, K. M., Griebeler, M. L., Kashyap, S. R., Rosenthal, R. J., Burguera, B., & Nissen, S. E. (2021). Association of prior metabolic and bariatric surgery with severity of coronavirus disease 2019 (COVID-19) in patients with obesity. Surgery for Obesity and Related Diseases, 17(1).

Anker, M. S., Landmesser, U., von Haehling, S., Butler, J., Coats, A. J. S., & Anker, S. D. (2021). Weight loss, malnutrition, and cachexia in COVID-19: facts and numbers. In Journal of Cachexia, Sarcopenia and Muscle (Vol. 12, Issue 1).

Bullard, T., Medcalf, A., Rethorst, C., & Foster, G. D. (2021). Impact of the COVID-19 pandemic on initial weight loss in a digital weight management program: A natural experiment. Obesity, 29(9).

Carfì, A., Bernabei, R., Landi, F., & Group, for the G. A. C.-19 P.-A. C. S. (2020). Persistent Symptoms in Patients After Acute COVID-19. JAMA, 324(6), 603–605.

Collaborative, Covids. (2020). Delaying surgery for patients with a previous SARS-CoV-2 infection. British Journal of Surgery, 107(12), e601–e602.

Conceição, E., de Lourdes, M., Ramalho, S., Félix, S., Pinto-Bastos, A., & Vaz, A. R. (2021). Eating behaviors and weight outcomes in bariatric surgery patients amidst COVID-19. Surgery for Obesity and Related Diseases, 17(6).

Dexter, F., Elhakim, M., Loftus, R. W., Seering, M. S., & Epstein, R. H. (2020). Strategies for daily operating room management of ambulatory surgery centers following resolution of the acute phase of the COVID-19 pandemic. Journal of Clinical Anesthesia, 64.

Di Filippo, L., De Lorenzo, R., D’Amico, M., Sofia, V., Roveri, L., Mele, R., Saibene, A., Rovere-Querini, P., & Conte, C. (2021). COVID-19 is associated with clinically significant weight loss and risk of malnutrition, independent of hospitalisation: A post-hoc analysis of a prospective cohort study. Clinical Nutrition, 40(4).

Kikutani, T., Ichikawa, Y., Kitazume, E., Mizukoshi, A., Tohara, T., Takahashi, N., Tamura, F., Matsutani, M., Onishi, J., & Makino, E. (2021). COVID-19 infection-related weight loss decreases eating/swallowing function in schizophrenic patients. Nutrients, 13(4).

What does efficiency in healthcare delivery mean? Examples of two market failures

October 08, 2021 3:41 pm


Economic efficiency measures system performance (Enrique & Marta, 2020); the Healthcare delivery system (HCDS) is no different. In non-biologic systems, the efficiency can be measured and optimized since all variables are predictable. However, efficiency becomes a complex and possibly unachievable task in a biological environment such as HCDS. The summary report will define the efficiency and examine the limitation of achieving efficiency in the healthcare delivery system.


Efficiency measures the adeptness of a system allowing identification of the inadequacies and opportunities for improvement. Economic efficiency minimizes cost and maximizes production for profit (Petrou, 2014).

Healthcare is a commodity (Mills & Gilson, 2009).  Increased need and limited resources, environment, illnesses are forces on an equilibrium of efficiency that requires flexibility. These are why economically competitive markets fail to achieve healthcare efficiency (Johansen & van den Bosch, 2017).

The concept of efficiency in health care has been described as Technical, Productive, and Allocative (Palmer & Torgerson, 1999). Extensive work has looked at special measures and populations for optimizing efficiency (Cylus & Papanicolas, 2016).

Efficient systems require predictable input, components, processes, and output, unlike efficiency in HCDS. The differences include:

  • Biologic environments introduce variability in the system. Therefore, the HCDS efficiency will need to be flexible to diversity. Unfortunately, flexibility and efficiency counteract each other at industrial levels (Adler et al., 1999; AHRENS & CHAPMAN, 2004), and thus inefficiency is to be expected.
  • Efficiency can be measured at two points:
    1. Efficiency of delivery
    2. Efficiency of outcome

Efficiency in HCDS means providing the most cost-efficient healthcare to those in need. As equity is a pillar of the HCDS, efficiency and equity are opposing forces (Guinness et al., 2011). Therefore, it is critical to have the broader determinants of health into consideration on HCDS. This broad spectrum of variables, individual level, and upstream factors (Dahlgren G & Whitehead M, 1991)  will affect efficiency models applicable in one setting for a given population and inefficient in another (Hussey et al., 2009).

Healthcare Market:

The principle of maximizing profits applies to the four market types[1][2]. However, healthcare markets achieve Social Efficiency[3] and not economic efficiency (Folland & Goodman, 2013). This is due to Asymmetry of the information, Adverse selection, Moral hazard, Independent supply and demand stresses, and Externalities (Mwachofi & Al-Assaf, 2011).

Examples of Market Failure

At the onset of the pandemic, most governments, WHO assumed the costs of COVID-19 vaccination as they became available. Social media has disseminated incorrect information on vaccines (Lin et al., 2020; Wajahat Hussain, 2020). The Asymmetry of the information (AOI) has resulted in a sizable portion of the eligible population not being vaccinated (Coe et al., 2021; Malik et al., 2020). HCDS’s failure is a public relations problem and a breakdown in the trust of institutions (Soares et al., 2021).

Adverse selection (AS) compounds the AOI. There have been pockets of efficiency in vaccination with no equity for the world population (Mathieu et al., 2021).

This is due to the AOI and the structural inequities in HCDS (Hyder et al., 2021). Few countries are offering vaccine boosters, where most of the world’s population has not received any.



Adler, P. S., Goldoftas, B., & Levine, D. I. (1999). Flexibility Versus Efficiency? A Case Study of Model Changeovers in the Toyota Production System. Organization Science, 10(1), 43–68.

Adler, P. S., Goldoftas, B., & Levine, D. I. (1999). Flexibility Versus Efficiency? A Case Study of Model Changeovers in the Toyota Production System. Organization Science, 10(1), 43–68.

AHRENS, T., & CHAPMAN, C. S. (2004). Accounting for Flexibility and Efficiency: A Field Study of Management Control Systems in a Restaurant Chain*. Contemporary Accounting Research, 21(2), 271–301.

Coe, A. B., Elliott, M. H., Gatewood, S. B. S., Goode, J. V. R., & Moczygemba, L. R. (2021). Perceptions and predictors of intention to receive the COVID-19 vaccine. Research in Social and Administrative Pharmacy.

Cylus, J., & Papanicolas, I. (2016). Health System Efficiency 46 How to make measurement matter for policy and management. London.

Dahlgren G, & Whitehead M. (1991). Dahlgren and Whitehead (1991) – Policies and strategies to promote social equity in health. Stockholm: Institute for future studies. Dahlgren G, Whitehead M. Retrieved from

Enrique, B., & Marta, B. (2020). Efficacy, Effectiveness and Efficiency in the Health Care: The Need for an Agreement to Clarify its Meaning. International Archives of Public Health and Community Medicine, 4(1).

Folland, S., & Goodman, A. (2013). The Economics of Health and Health Care. Oakland: Pearson.

Guinness, L., Wiseman, V., & Wonderling, D. (2011). Introduction to health economics. (2nd ed. /). Maidenhead: McGraw-Hill/Open University Press.

Hussey, P. S., de Vries, H., Romley, J., Wang, M. C., Chen, S. S., Shekelle, P. G., & McGlynn, E. A. (2009). A systematic review of health care efficiency measures. Health Services Research, 44(3), 784–805.

Hyder, A. A., Hyder, M. A., Nasir, K., & Ndebele, P. (2021). Inequitable COVID-19 vaccine distribution and its effects. Bulletin of the World Health Organization, 99(6), 406-406A.

Johansen, F., & van den Bosch, S. (2017). The scaling-up of Neighbourhood Care: From experiment towards a transformative movement in healthcare. Futures, 89, 60–73.

Lin, C. Y., Broström, A., Griffiths, M. D., & Pakpour, A. H. (2020). Investigating mediated effects of fear of COVID-19 and COVID-19 misunderstanding in the association between problematic social media use, psychological distress, and insomnia. Internet Interventions, 21.

Malik, A. A., McFadden, S. A. M., Elharake, J., & Omer, S. B. (2020). Determinants of COVID-19 vaccine acceptance in the US. EClinicalMedicine, 26.

Mathieu, E., Ritchie, H., Ortiz-Ospina, E., Roser, M., Hasell, J., Appel, C., … Rodés-Guirao, L. (2021). A global database of COVID-19 vaccinations. Nature Human Behaviour, 5(7), 947–953.

Mills, A., & Gilson, L. (2009). Health Economics for Developing Countries: A Survival Kit. Esocialsciences.Com, Working Papers.

Mwachofi, A., & Al-Assaf, A. F. (2011). Health care market deviations from the ideal market. Sultan Qaboos University Medical Journal, 11(3), 328–337. Retrieved from

Palmer, S., & Torgerson, D. J. (1999). Economic notes: definitions of efficiency. BMJ (Clinical Research Ed.), 318(7191), 1136.

Petrou, A. (2014). Economic Efficiency. In A. C. Michalos (Ed.), Encyclopedia of Quality of Life and Well-Being Research (pp. 1793–1794). Dordrecht: Springer Netherlands.

Soares, P., Rocha, J. V., Moniz, M., Gama, A., Laires, P. A., Pedro, A. R., … Nunes, C. (2021). Factors associated with COVID-19 vaccine hesitancy. Vaccines, 9(3).

Wajahat Hussain. (2020). Role of Social Media in COVID-19 Pandemic. The International Journal of Frontier Sciences, 4(2), 59–60.

[1] Perfect competition, Monopoly, Oligopoly, Monopolistic competition

[2] Control of Total revenue (TR) and Cost (TC) to maximize profit

[3] An equilibrium point (Pareto Optimality) where Social Marginal Benefit (SMB) and the Cost (SMC) are equal

Medication Accumulation in Gut Bacteria May Curb Drug Effectiveness, Alter Gut Microbiome

October 05, 2021 2:06 pm

NEW YORK (Reuters Health) – Many common medications such as antidepressants, diabetes and asthma drugs can accumulate in gut bacteria, altering bacterial function and potentially reducing drug effectiveness, researchers say. “It was surprising that the majority of the new interactions we saw between bacteria and drugs were the drugs accumulating in the bacteria, because up until now biotransformation (chemical modification) was thought to be the only way that bacteria affect drug availability,” Dr. Kiran Patil of the MRC Toxicology Unit, University of Cambridge, told Reuters Health by email. “We also were surprised to see the stark effect of bioaccumulation on bacterial metabolism and on community composition.” “There will likely be very strong differences between individuals, depending on the composition of their gut microbiota,” he noted. “We saw differences even between different strains of the same species of bacteria.” As reported in Nature, Dr. Patil and colleagues grew 25 common strains of gut bacteria and investigated their interactions with 15 structurally diverse oral drugs. The team identified 70 bacteria-drug interactions, 29 of which had not been previously reported. Seventeen of the newly discovered interactions could be ascribed to bioaccumulation – i.e., bacteria storing the drug intracellularly without chemically modifying it, and in most cases without bacterial growth being affected. To gain additional insight, the team investigated the molecular basis of bioaccumulation of the antidepressant duloxetine. They found that duloxetine binds to several metabolic enzymes and changes the metabolite secretion of the affected bacteria. When tested in a microbial community of drug accumulators and non-accumulators, duloxetine markedly altered the small molecules produced by the drug-accumulating bacteria, which the non-accumulators fed on; this caused an overabundance of consuming bacteria, thereby unbalancing the composition of the community. Further, the team validated their findings in C. elegans; worms grown in bacteria that accumulated duloxetine behaved differently from those grown in bacteria that did not accumulate duloxetine. Summing up, the authors state, “Together, our results show that bioaccumulation by gut bacteria may be a common mechanism that alters drug availability and bacterial metabolism, with implications for microbiota composition, pharmacokinetics, side effects and drug responses, probably in an individual manner.” Dr. Patil added, “Next steps will be to take forward this basic molecular research and investigate how an individual’s gut bacteria tie in with differing individual responses to drugs such as antidepressants – differences in response, drug dose needed, and side effects like weight gain.” “If we can characterize how people respond depending on the composition of their microbiome, then drug treatments could be individualized,” he said. “The clinical relevance will hopefully be clear in the next 2-3 years.” Dr. Libusha Kelly of Albert Einstein College of Medicine in New York City commented on the study in an email to Reuters Health, “This work highlights the broad importance of microbe/drug interactions in drug bioavailability and the unrecognized potential for bioaccumulation of drugs to modify metabolite secretion in microbial communities.” “As the authors note,” she said, “this study in bacterial isolates is only the first step towards understanding how bioaccumulation might influence drug metabolism and microbial community composition in the context of the far more complicated communities of microbes in the human body.”
“There are likely additional, cryptic, ways in which bacteria alter bioavailability and drug metabolism in the human body,” she said. “Furthermore, we do not understand how microbiome/drug interactions influence drug efficacy and safety in individual patients, which limits the clinical utility of our field currently. However, the authors uncover an exciting direction for future research.” Source: Nature, online September 8, 2021. Reuters Health Information © 2021

Oral Vitmain D

September 24, 2021 3:42 pm

We have had positive feedback from patients who have had Replesta Vitmain D shewable wafers. There are some cost considerations, when compared to the cheeper alternatives. The follow up labs have also shown improvement for the patients who have tried Replesta, compared to alternatives with better results. Note that this is not a product placement, as there is no financial interest to report.

Over the Coubnter Vitmain D3 better than the Prescription Vitamin D2

August 30, 2021 10:41 am

Vitamin D absorption is based on a complex series of pathways in the human body. We have discussed the significance of Vitamin D in a broad health condition, including Covid-19, immune system and bone structures. These articles explain the differences in detail. We have no finaicial insterst in the recommendations made on our site.

COVID Vaccines

March 05, 2021 3:50 pm

There are no known contraindications from a weight-loss surgical perspective to prevent a post-surgical patient from getting the COVID vaccines.

A patient who has had a Duodenal Switch, Lap Sleeve Gastrectomy, RNY Gastric Bypass, or revisions to Weight Loss Surgery should have the COVID vaccine. The vaccination should be avoided for a few weeks after surgery. For other possible contraindications, please consult your PCP.

Here is a summary of the vaccines and the details of each one approved as of the publication date.




All about vaccines?

February 14, 2021 2:41 pm

There is a lot of incorrect information on non-medical mass media about vaccines. Vaccines have been instrumental in our well being. As we face the challenge of COVID-19, our medical decisions must be made based on facts. Here are some interesting and concise descriptions of How do vaccines work? How are vaccines developed?  How are vaccines manufactured?   The source of all this information is WHO.

Vitamin D, Immune Responce and COVID-19

January 26, 2021 6:45 pm

Regardless of whether vitamin D protects against COVID-19, adequate levels are important for bone health. “Avoiding vitamin D deficiency is always a goal,” Ross wrote. “If the diet doesn’t include vitamin D fortified milk or natural products like fish, then a supplement of the RDA [recommended dietary allowance] amount (600-1000 IU per day) provides good assurance. I consider this a ‘good idea,’ but I don’t want to leave the impression that diet cannot be sufficient.”
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