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Article Category: Metabolic, Nutrition, Vitamins and Pregnancy
Sucralose: Heating above 120°C can produce substances that are harmful to health (BfR Communication 15/2026)
Date of Publication: 2026
Germany’s Federal Institute for Risk Assessment (BfR) summarizes the 2026 EFSA re-evaluation of sucralose and continues to advise against heating sucralose-containing foods to baking, frying or roasting temperatures, recommending that sucralose be added only after cooking. Discussed in our blog post on whether sucralose (Splenda) is bad for you.
Use of non-sugar sweeteners: WHO guideline
Date of Publication: 2023
The World Health Organization’s 2023 guideline on non-sugar sweeteners, which conditionally recommends against using them as a long-term strategy for weight control or for reducing the risk of diet-related noncommunicable diseases, citing a lack of convincing long-term benefit and possible associations with adverse outcomes. Discussed in our blog post on whether sucralose (Splenda) is bad for you.
Effect of sucralose and aspartame on glucose metabolism and gut hormones
Date of Publication: 2020
A 2020 review in Nutrition Reviews of clinical trials on how sucralose and aspartame affect blood glucose, insulin and gut hormones such as GLP-1. Most studies found no effect on these measures, while a minority reported changes in glucose, insulin sensitivity or GLP-1; the authors attribute the conflicting results largely to differences in study design. The full text is available from the publisher (Oxford University Press) via the link above. Referenced in our blog post on whether sucralose (Splenda) is bad for you.
Re-evaluation of sucralose (E 955) as a food additive and evaluation of a new application on extension of use of sucralose (E 955) in fine bakery wares
Date of Publication: 2026
The European Food Safety Authority’s 2026 scientific opinion re-evaluating the sweetener sucralose (E 955). The Panel kept the acceptable daily intake at 15 mg/kg body weight per day and found no safety concern at current use levels, but could not rule out the formation of potentially harmful chlorinated compounds when sucralose is heated to high temperatures, as in baking. Discussed in our blog post on whether sucralose (Splenda) is bad for you. Licence: CC BY-ND 4.0.
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Date of Publication: 2026
This 2026 systematic review and meta-analysis pooled randomized controlled trials in healthy adults and found that, in the short term, sucralose did not significantly change gut microbial diversity, fasting blood glucose or insulin resistance. The authors call for longer, standardized trials. Discussed in our blog post on whether sucralose (Splenda) is bad for you. Open access (CC BY 4.0).
Annual injection of vitamin D and fractures of aged bones
Date of Publication: 1992
C-Reactive Protein Decrease After Postbariatric Abdominoplasty
Date of Publication: 2011
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