Citation : Wulandari DT, Andarwulan N, Saraswati, et al. Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Int J Mol Sci. 2026;27(18):8377. doi:10.3390/ijms27188377
Link to Scientific Article :
Effect of Sucralose Consumption on Gut Microbiota: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Date of Publication: 2026
This 2026 systematic review and meta-analysis pooled randomized controlled trials in healthy adults and found that, in the short term, sucralose did not significantly change gut microbial diversity, fasting blood glucose or insulin resistance. The authors call for longer, standardized trials. Discussed in our blog post on whether sucralose (Splenda) is bad for you. Open access (CC BY 4.0).