Posted On : December 16, 2024 Our body has to maintain a narrow acid-base balance, PH (7.35-7.45) in the bloodstream. This is accomplished by a highly regulated system that involves multiple organs. Kidneys, liver, Lung, and  GI tract all interact with each other to maintain the normal environment. For example, in a chronic smoker, there is a build-up of carbon dioxide, which develops respiratory acidosis. This acidosis may be partially corrected and compensated for by retaining bicarbonate to keep the blood PH in the normal range.