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	<title>Nutrition Archives - DSSurgery</title>
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	<description>Duodenal Switch &#38; Gastric Sleeve Weight Loss Surgery in Los Angeles, CA</description>
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		<title>Feeding Tube with Duodenal Switch</title>
		<link>https://www.dssurgery.com/feeding-tube-with-duodenal-switch/</link>
					<comments>https://www.dssurgery.com/feeding-tube-with-duodenal-switch/#respond</comments>
		
		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Mon, 03 Feb 2025 17:53:10 +0000</pubDate>
				<category><![CDATA[Anatomy]]></category>
		<category><![CDATA[Bariatric surgery]]></category>
		<category><![CDATA[BPD]]></category>
		<category><![CDATA[BPD/DS]]></category>
		<category><![CDATA[Duodenal Switch]]></category>
		<category><![CDATA[feeding jejunostomy]]></category>
		<category><![CDATA[feeding tube]]></category>
		<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[nutritional deficiencies]]></category>
		<category><![CDATA[failed gastric bypass]]></category>
		<category><![CDATA[fedding tube]]></category>
		<category><![CDATA[malnutrition]]></category>
		<category><![CDATA[nutrition]]></category>
		<guid isPermaLink="false">https://www.dssurgery.com/?p=13829</guid>

					<description><![CDATA[<p>The surgical changes following the revision of the failed gastric bypass to the duodenal switch or a primary duodenal switch require an evident appreciation and understanding of the anatomy and physiology of placing a feeding tube and managing the nutritional status. There are different places where a feeding tube can be placed. 1-A feeding gastrostomy […] <a class="moretag btn btn-primary btn-xs" href="https://www.dssurgery.com/feeding-tube-with-duodenal-switch/"> Read the Full Article</a></p>
<p>The post <a href="https://www.dssurgery.com/feeding-tube-with-duodenal-switch/">Feeding Tube with Duodenal Switch</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
										<content:encoded><![CDATA[<p style="font-weight: 400;">The surgical changes following the revision of the failed gastric bypass to the duodenal switch or a primary duodenal switch require an evident appreciation and understanding of the anatomy and physiology of placing a <a href="https://www.dssurgery.com/feeding-tube/" target="_blank" rel="noopener">feeding tube</a> and managing the nutritional status. There are <a href="https://www.dssurgery.com/blog/what-is-a-feeding-tube/" target="_blank" rel="noopener">different places where a feeding tube can be placed</a>.</p>
<p style="font-weight: 400;">1-A feeding gastrostomy tube endoscopically cannot be placed because of the <a href="https://www.dssurgery.com/weight-loss-surgery/compare-procedures/normal-anatomy-compared-to-duodenal-switch/" target="_blank" rel="noopener">transected post-pyloric duodenum</a> (The image viewed on a desktop or a laptop allows the scroller on the image to move)</p>
<p style="font-weight: 400;">2-An orogastric or nasogastric tube should only use an elemental feeding formula. This is because the food in the stomach is prevented from mixing with the biliopancreatic juices, which will not be adequately absorbed.</p>
<p style="font-weight: 400;">3-A feeding Jejunostomy can only be insured surgical post ligament of traits. This cannot be done endoscopically because duodenal switch transaction post pyloric small bowel to prevent mixing of the biliopancreatic secretion.</p>
&nbsp;

<a href="https://www.dssurgery.com/?s=feeding+tube" target="_blank" rel="noopener">Additional information </a><p>The post <a href="https://www.dssurgery.com/feeding-tube-with-duodenal-switch/">Feeding Tube with Duodenal Switch</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>Cheers! Alcohol Metabolism</title>
		<link>https://www.dssurgery.com/cheers-alcohol-metabolism/</link>
					<comments>https://www.dssurgery.com/cheers-alcohol-metabolism/#respond</comments>
		
		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Tue, 17 Dec 2024 21:59:30 +0000</pubDate>
				<category><![CDATA[Absorption]]></category>
		<category><![CDATA[Alcohol]]></category>
		<category><![CDATA[Calorie count]]></category>
		<category><![CDATA[malnutrition]]></category>
		<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[weight gain]]></category>
		<category><![CDATA[Weight Loss Surgery]]></category>
		<category><![CDATA[alcohol]]></category>
		<category><![CDATA[nutrition]]></category>
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					<description><![CDATA[<p>The post <a href="https://www.dssurgery.com/cheers-alcohol-metabolism/">Cheers! Alcohol Metabolism</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
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			<p>Cheers! Let&#8217;s take a minute to look at alcohol metabolism. It&#8217;s that time of year when it seems we are going from one Holiday or Christmas party to another, and then we get together with the family and have a little more alcohol. The following diagram shows how alcohol metabolism takes place.</p>
<p><a href="https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2.jpg"><img fetchpriority="high" decoding="async" class="alignnone size-large wp-image-13708" src="https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2-1024x576.jpg" alt="" width="1024" height="576" srcset="https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2-1024x576.jpg 1024w, https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2-300x169.jpg 300w, https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2-1536x864.jpg 1536w, https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2-600x338.jpg 600w, https://www.dssurgery.com/wp-content/uploads/2024/12/Presentation2.jpg 1960w" sizes="(max-width: 1024px) 100vw, 1024px" /></a></p>
<p>Alcohol is a caloric intake, and we all need to keep close tabs on it. <a href="https://www.delish.com/food/a50819/calories-in-every-kind-of-alcohol/?epik=dj0yJnU9MHhhb0xlYW5FbEhTdFM0d2tsMEw2NnQ2Ykw4b18zS0gmcD0wJm49cmhlOXplN3M3UDNnX3pRZlFGNi16QSZ0PUFBQUFBR2RpR2Zn">Alcohol</a> is very easily metabolized and the calories add up quickly.  Every stage of alcohol processing in the liver involves the extraction of calories and free radicals, which are toxins. Excess calories not used in bodily functions can be stored as fat mass. Alcohol can be a  roadblock in weight loss. Those drinks add up!</p>
<p><img decoding="async" class="alignnone size-medium wp-image-13699" src="https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.40.43 PM-297x300.png" alt="Alcohol Calorie Count" width="297" height="300" srcset="https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.40.43 PM-297x300.png 297w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.40.43 PM-1015x1024.png 1015w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.40.43 PM-600x605.png 600w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.40.43 PM-100x100.png 100w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.40.43 PM.png 1118w" sizes="(max-width: 297px) 100vw, 297px" /><img decoding="async" class="alignnone size-medium wp-image-13700" src="https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.37.44 PM-273x300.png" alt="" width="273" height="300" srcset="https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.37.44 PM-273x300.png 273w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.37.44 PM-932x1024.png 932w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.37.44 PM-600x659.png 600w, https://www.dssurgery.com/wp-content/uploads/2024/12/Screenshot-2024-12-17-at-4.37.44 PM.png 1127w" sizes="(max-width: 273px) 100vw, 273px" /></p>
<p>Here is a <a href="https://youtu.be/XJ63o8hyjEw" target="_blank" rel="noopener">short video</a> as a reminder while everyone waits to get ready for the next party.</p>
<p>Happy holidays.</p>
<p>A newsletter post from 2004 regarding the effects of <a href="https://www.dssurgery.com/wp-content/uploads/2004/12/newsletter-dec-jan-05.pdf">alcohol and weight loss surgery. </a></p>

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		<title>What does efficiency in healthcare delivery mean? Examples of  two market failures</title>
		<link>https://www.dssurgery.com/what-does-efficiency-in-healthcare-delivery-mean-examples-of-two-market-failures/</link>
					<comments>https://www.dssurgery.com/what-does-efficiency-in-healthcare-delivery-mean-examples-of-two-market-failures/#respond</comments>
		
		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Fri, 08 Oct 2021 23:41:44 +0000</pubDate>
				<category><![CDATA[Coronavirus]]></category>
		<category><![CDATA[Covid_19]]></category>
		<category><![CDATA[COVID-19]]></category>
		<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[Public Health]]></category>
		<category><![CDATA[Uncategorized]]></category>
		<category><![CDATA[COVID]]></category>
		<category><![CDATA[health insurance]]></category>
		<category><![CDATA[Public health]]></category>
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					<description><![CDATA[<p>The post <a href="https://www.dssurgery.com/what-does-efficiency-in-healthcare-delivery-mean-examples-of-two-market-failures/">What does efficiency in healthcare delivery mean? Examples of  two market failures</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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			<p><strong>Introduction:</strong></p>
<p>Economic efficiency measures system performance (Enrique &amp; Marta, 2020); the Healthcare delivery system (HCDS) is no different. In non-biologic systems, the efficiency can be measured and optimized since all variables are predictable. However, efficiency becomes a complex and possibly unachievable task in a biological environment such as HCDS. The summary report will define the efficiency and examine the limitation of achieving efficiency in the healthcare delivery system.</p>
<p><strong>Definitions:</strong></p>
<p>Efficiency measures the adeptness of a system allowing identification of the inadequacies and opportunities for improvement. Economic efficiency minimizes cost and maximizes production for profit (Petrou, 2014).</p>
<p>Healthcare is a commodity (Mills &amp; Gilson, 2009).  Increased need and limited resources, environment, illnesses are forces on an equilibrium of efficiency that requires flexibility. These are why economically competitive markets fail to achieve healthcare efficiency (Johansen &amp; van den Bosch, 2017).</p>
<p>The concept of efficiency in health care has been described as Technical, Productive, and Allocative (Palmer &amp; Torgerson, 1999). Extensive work has looked at special measures and populations for optimizing efficiency (Cylus &amp; Papanicolas, 2016).</p>
<p>Efficient systems require predictable input, components, processes, and output, unlike efficiency in HCDS. The differences include:</p>
<ul>
<li>Biologic environments introduce variability in the system. Therefore, the HCDS efficiency will need to be flexible to diversity. Unfortunately, flexibility and efficiency counteract each other at industrial levels (Adler et al., 1999; AHRENS &amp; CHAPMAN, 2004), and thus inefficiency is to be expected.</li>
<li>Efficiency can be measured at two points:
<ol>
<li>Efficiency of delivery</li>
<li>Efficiency of outcome</li>
</ol>
</li>
</ul>
<p>Efficiency in HCDS means providing the most cost-efficient healthcare to those in need. As equity is a pillar of the HCDS, efficiency and equity are opposing forces (Guinness et al., 2011). Therefore, it is critical to have the broader determinants of health into consideration on HCDS. This broad spectrum of variables, individual level, and upstream factors (Dahlgren G &amp; Whitehead M, 1991)  will affect efficiency models applicable in one setting for a given population and inefficient in another (Hussey et al., 2009).</p>
<p><strong>Healthcare Market:</strong></p>
<p>The principle of maximizing profits applies to the four market types<a href="applewebdata://C4F3666E-9844-4E04-8167-2D5787FA156F#_ftn1" name="_ftnref1">[1]</a><a href="applewebdata://C4F3666E-9844-4E04-8167-2D5787FA156F#_ftn2" name="_ftnref2">[2]</a>. However, healthcare markets achieve Social Efficiency<a href="applewebdata://C4F3666E-9844-4E04-8167-2D5787FA156F#_ftn3" name="_ftnref3">[3]</a> and not economic efficiency (Folland &amp; Goodman, 2013). This is due to Asymmetry of the information, Adverse selection, Moral hazard, Independent supply and demand stresses, and Externalities (Mwachofi &amp; Al-Assaf, 2011).</p>
<p><em><u>Examples</u></em> of Market Failure</p>
<p>At the onset of the pandemic, most governments, WHO assumed the costs of COVID-19 vaccination as they became available. Social media has disseminated incorrect information on vaccines (Lin et al., 2020; Wajahat Hussain, 2020). The <em><u>Asymmetry of the information (AOI)</u></em> has resulted in a sizable portion of the eligible population not being vaccinated (Coe et al., 2021; Malik et al., 2020). HCDS’s failure is a public relations problem and a breakdown in the trust of institutions (Soares et al., 2021).</p>
<p><em><u>Adverse selection (AS)</u></em> compounds the AOI. There have been pockets of efficiency in vaccination with no equity for the world population (Mathieu et al., 2021).</p>
<p><a href="https://www.dssurgery.com/wp-content/uploads/2021/10/Picture1.png"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-10612" src="https://www.dssurgery.com/wp-content/uploads/2021/10/Picture1-1024x721.png" alt="" width="1024" height="721" srcset="https://www.dssurgery.com/wp-content/uploads/2021/10/Picture1-1024x721.png 1024w, https://www.dssurgery.com/wp-content/uploads/2021/10/Picture1-300x211.png 300w, https://www.dssurgery.com/wp-content/uploads/2021/10/Picture1-600x423.png 600w, https://www.dssurgery.com/wp-content/uploads/2021/10/Picture1.png 1249w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></a>This is due to the AOI and the structural inequities in HCDS (Hyder et al., 2021). Few countries are offering vaccine boosters, where most of the world’s population has not received any.</p>
<p>&nbsp;</p>
<p>References:</p>
<p>Adler, P. S., Goldoftas, B., &amp; Levine, D. I. (1999). Flexibility Versus Efficiency? A Case Study of Model Changeovers in the Toyota Production System. <em>Organization Science</em>, <em>10</em>(1), 43–68. https://doi.org/10.1287/orsc.10.1.43</p>
<p>Adler, P. S., Goldoftas, B., &amp; Levine, D. I. (1999). Flexibility Versus Efficiency? A Case Study of Model Changeovers in the Toyota Production System. <em>Organization Science</em>, <em>10</em>(1), 43–68. https://doi.org/10.1287/orsc.10.1.43</p>
<p>AHRENS, T., &amp; CHAPMAN, C. S. (2004). Accounting for Flexibility and Efficiency: A Field Study of Management Control Systems in a Restaurant Chain*. <em>Contemporary Accounting Research</em>, <em>21</em>(2), 271–301. https://doi.org/https://doi.org/10.1506/VJR6-RP75-7GUX-XH0X</p>
<p>Coe, A. B., Elliott, M. H., Gatewood, S. B. S., Goode, J. V. R., &amp; Moczygemba, L. R. (2021). Perceptions and predictors of intention to receive the COVID-19 vaccine. <em>Research in Social and Administrative Pharmacy</em>. https://doi.org/10.1016/j.sapharm.2021.04.023</p>
<p>Cylus, J., &amp; Papanicolas, I. (2016). <em>Health System Efficiency 46 How to make measurement matter for policy and management</em>. London.</p>
<p>Dahlgren G, &amp; Whitehead M. (1991). <em>Dahlgren and Whitehead (1991) &#8211; Policies and strategies to promote social equity in health. Stockholm: Institute for future studies</em>. <em>Dahlgren G, Whitehead M</em>. Retrieved from https://core.ac.uk/display/6472456</p>
<p>Enrique, B., &amp; Marta, B. (2020). Efficacy, Effectiveness and Efficiency in the Health Care: The Need for an Agreement to Clarify its Meaning. <em>International Archives of Public Health and Community Medicine</em>, <em>4</em>(1). https://doi.org/10.23937/2643-4512/1710035</p>
<p>Folland, S., &amp; Goodman, A. (2013). <em>The Economics of Health and Health Care</em>. Oakland: Pearson.</p>
<p>Guinness, L., Wiseman, V., &amp; Wonderling, D. (2011). <em>Introduction to health economics.</em> (2nd ed. /). Maidenhead: McGraw-Hill/Open University Press.</p>
<p>Hussey, P. S., de Vries, H., Romley, J., Wang, M. C., Chen, S. S., Shekelle, P. G., &amp; McGlynn, E. A. (2009). A systematic review of health care efficiency measures. <em>Health Services Research</em>, <em>44</em>(3), 784–805. https://doi.org/10.1111/j.1475-6773.2008.00942.x</p>
<p>Hyder, A. A., Hyder, M. A., Nasir, K., &amp; Ndebele, P. (2021). Inequitable COVID-19 vaccine distribution and its effects. <em>Bulletin of the World Health Organization</em>, <em>99</em>(6), 406-406A. https://doi.org/10.2471/BLT.21.285616</p>
<p>Johansen, F., &amp; van den Bosch, S. (2017). The scaling-up of Neighbourhood Care: From experiment towards a transformative movement in healthcare. <em>Futures</em>, <em>89</em>, 60–73. https://doi.org/https://doi.org/10.1016/j.futures.2017.04.004</p>
<p>Lin, C. Y., Broström, A., Griffiths, M. D., &amp; Pakpour, A. H. (2020). Investigating mediated effects of fear of COVID-19 and COVID-19 misunderstanding in the association between problematic social media use, psychological distress, and insomnia. <em>Internet Interventions</em>, <em>21</em>. https://doi.org/10.1016/j.invent.2020.100345</p>
<p>Malik, A. A., McFadden, S. A. M., Elharake, J., &amp; Omer, S. B. (2020). Determinants of COVID-19 vaccine acceptance in the US. <em>EClinicalMedicine</em>, <em>26</em>. https://doi.org/10.1016/j.eclinm.2020.100495</p>
<p>Mathieu, E., Ritchie, H., Ortiz-Ospina, E., Roser, M., Hasell, J., Appel, C., … Rodés-Guirao, L. (2021). A global database of COVID-19 vaccinations. <em>Nature Human Behaviour</em>, <em>5</em>(7), 947–953. https://doi.org/10.1038/s41562-021-01122-8</p>
<p>Mills, A., &amp; Gilson, L. (2009). Health Economics for Developing Countries: A Survival Kit. <em>Esocialsciences.Com, Working Papers</em>.</p>
<p>Mwachofi, A., &amp; Al-Assaf, A. F. (2011). Health care market deviations from the ideal market. <em>Sultan Qaboos University Medical Journal</em>, <em>11</em>(3), 328–337. Retrieved from https://pubmed.ncbi.nlm.nih.gov/22087373</p>
<p>Palmer, S., &amp; Torgerson, D. J. (1999). Economic notes: definitions of efficiency. <em>BMJ (Clinical Research Ed.)</em>, <em>318</em>(7191), 1136. https://doi.org/10.1136/bmj.318.7191.1136</p>
<p>Petrou, A. (2014). Economic Efficiency. In A. C. Michalos (Ed.), <em>Encyclopedia of Quality of Life and Well-Being Research</em> (pp. 1793–1794). Dordrecht: Springer Netherlands. https://doi.org/10.1007/978-94-007-0753-5_818</p>
<p>Soares, P., Rocha, J. V., Moniz, M., Gama, A., Laires, P. A., Pedro, A. R., … Nunes, C. (2021). Factors associated with COVID-19 vaccine hesitancy. <em>Vaccines</em>, <em>9</em>(3). https://doi.org/10.3390/vaccines9030300</p>
<p>Wajahat Hussain. (2020). Role of Social Media in COVID-19 Pandemic. <em>The International Journal of Frontier Sciences</em>, <em>4</em>(2), 59–60. https://doi.org/10.37978/tijfs.v4i2.144</p>
<p><a href="applewebdata://C4F3666E-9844-4E04-8167-2D5787FA156F#_ftnref1" name="_ftn1">[1]</a> Perfect competition, Monopoly, Oligopoly, Monopolistic competition</p>
<p><a href="applewebdata://C4F3666E-9844-4E04-8167-2D5787FA156F#_ftnref2" name="_ftn2">[2]</a> Control of Total revenue (TR) and Cost (TC) to maximize profit</p>
<p><a href="applewebdata://C4F3666E-9844-4E04-8167-2D5787FA156F#_ftnref3" name="_ftn3">[3]</a> An equilibrium point (Pareto Optimality) where Social Marginal Benefit (SMB) and the Cost (SMC) are equal</p>

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</div><p>The post <a href="https://www.dssurgery.com/what-does-efficiency-in-healthcare-delivery-mean-examples-of-two-market-failures/">What does efficiency in healthcare delivery mean? Examples of  two market failures</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>Medication Accumulation in Gut Bacteria May Curb Drug Effectiveness, Alter Gut Microbiome</title>
		<link>https://www.dssurgery.com/medication-gut-bacteria-microbiome/</link>
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		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Tue, 05 Oct 2021 22:06:00 +0000</pubDate>
				<category><![CDATA[C.diff]]></category>
		<category><![CDATA[flatualence]]></category>
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		<category><![CDATA[gut microbiome]]></category>
		<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[prebioitics]]></category>
		<category><![CDATA[nutrition]]></category>
		<category><![CDATA[probiotics]]></category>
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					<description><![CDATA[<p>By Marilynn Larkin September 23, 2021 NEW YORK (Reuters Health) &#8211; Many common medications such as antidepressants, diabetes and asthma drugs can accumulate in gut bacteria, altering bacterial function and potentially reducing drug effectiveness, researchers say. &#8220;It was surprising that the majority of the new interactions we saw between bacteria and drugs were the drugs […] <a class="moretag btn btn-primary btn-xs" href="https://www.dssurgery.com/medication-gut-bacteria-microbiome/"> Read the Full Article</a></p>
<p>The post <a href="https://www.dssurgery.com/medication-gut-bacteria-microbiome/">Medication Accumulation in Gut Bacteria May Curb Drug Effectiveness, Alter Gut Microbiome</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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										<content:encoded><![CDATA[<div class="page" title="Page 1">
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<div class="section"><a href="https://www.medscape.com/viewarticle/959201?uac=122841CV&amp;faf=1&amp;sso=true&amp;impID=3663374&amp;src=wnl_edit_tpal" target="_blank" rel="noopener">By Marilynn Larkin September 23, 2021</a></div>
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NEW YORK (Reuters Health) &#8211; Many common medications such as antidepressants, diabetes and asthma drugs can accumulate in gut bacteria, altering bacterial function and potentially reducing drug effectiveness, researchers say.

&#8220;It was surprising that the majority of the new interactions we saw between bacteria and drugs were the drugs accumulating in the bacteria, because up until now biotransformation (chemical modification) was thought to be the only way that bacteria affect drug availability,&#8221; Dr. Kiran Patil of the MRC Toxicology Unit, University of Cambridge, told Reuters Health by email. &#8220;We also were surprised to see the stark effect of bioaccumulation on bacterial metabolism and on community composition.&#8221;

&#8220;There will likely be very strong differences between individuals, depending on the composition of their gut microbiota,&#8221; he noted. &#8220;We saw differences even between different strains of the same species of bacteria.&#8221;

As reported in Nature, Dr. Patil and colleagues grew 25 common strains of gut bacteria and investigated their interactions with 15 structurally diverse oral drugs.

The team identified 70 bacteria-drug interactions, 29 of which had not been previously reported.

Seventeen of the newly discovered interactions could be ascribed to bioaccumulation &#8211; i.e., bacteria storing the drug intracellularly without chemically modifying it, and in most cases without bacterial growth being affected.

To gain additional insight, the team investigated the molecular basis of bioaccumulation of the antidepressant duloxetine. They found that duloxetine binds to several metabolic enzymes and changes the metabolite secretion of the affected bacteria.

When tested in a microbial community of drug accumulators and non-accumulators, duloxetine markedly altered the small molecules produced by the drug-accumulating bacteria, which the non-accumulators fed on; this caused an overabundance of consuming bacteria, thereby unbalancing the composition of the community.

Further, the team validated their findings in C. elegans; worms grown in bacteria that accumulated duloxetine behaved differently from those grown in bacteria that did not accumulate duloxetine.

Summing up, the authors state, &#8220;Together, our results show that bioaccumulation by gut bacteria may be a common mechanism that alters drug availability and bacterial metabolism, with implications for microbiota composition, pharmacokinetics, side effects and drug responses, probably in an individual manner.&#8221;

Dr. Patil added, &#8220;Next steps will be to take forward this basic molecular research and investigate how an individual&#8217;s gut bacteria tie in with differing individual responses to drugs such as antidepressants &#8211; differences in response, drug dose needed, and side effects like weight gain.&#8221;

&#8220;If we can characterize how people respond depending on the composition of their microbiome, then drug treatments could be individualized,&#8221; he said. &#8220;The clinical relevance will hopefully be clear in the next 2-3 years.&#8221;

Dr. Libusha Kelly of Albert Einstein College of Medicine in New York City commented on the study in an email to Reuters Health, &#8220;This work highlights the broad importance of microbe/drug interactions in drug bioavailability and the unrecognized potential for bioaccumulation of drugs to modify metabolite secretion in microbial communities.&#8221;

<a href="https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM.png"><img loading="lazy" decoding="async" class="alignnone size-large wp-image-10606" src="https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM-1024x707.png" alt="" width="1024" height="707" srcset="https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM-1024x707.png 1024w, https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM-300x207.png 300w, https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM-1536x1061.png 1536w, https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM-2048x1414.png 2048w, https://www.dssurgery.com/wp-content/uploads/2021/10/Screen-Shot-2021-10-05-at-2.05.25-PM-600x414.png 600w" sizes="auto, (max-width: 1024px) 100vw, 1024px" /></a>

&#8220;As the authors note,&#8221; she said, &#8220;this study in bacterial isolates is only the first step towards understanding how bioaccumulation might influence drug metabolism and microbial community composition in the context of the far more complicated communities of microbes in the human body.&#8221;

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&#8220;There are likely additional, cryptic, ways in which bacteria alter bioavailability and drug metabolism in the human body,&#8221; she said. &#8220;Furthermore, we do not understand how microbiome/drug interactions influence drug efficacy and safety in individual patients, which limits the clinical utility of our field currently. However, the authors uncover an exciting direction for future research.&#8221;

Source:

<a href="https://www.nature.com/articles/s41586-021-03891-8" target="_blank" rel="noopener">https://go.nature.com/3CxioHd</a>

Nature, online September 8, 2021. Reuters Health Information © 2021

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</div><p>The post <a href="https://www.dssurgery.com/medication-gut-bacteria-microbiome/">Medication Accumulation in Gut Bacteria May Curb Drug Effectiveness, Alter Gut Microbiome</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>What’s New With the Nutrition Facts Label?</title>
		<link>https://www.dssurgery.com/whats-new-with-the-nutrition-facts-label/</link>
					<comments>https://www.dssurgery.com/whats-new-with-the-nutrition-facts-label/#comments</comments>
		
		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Tue, 08 Dec 2020 06:28:35 +0000</pubDate>
				<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[post op diet]]></category>
		<category><![CDATA[post operative diet]]></category>
		<category><![CDATA[nutrition]]></category>
		<guid isPermaLink="false">https://www.dssurgery.com/?p=9648</guid>

					<description><![CDATA[<p>The Federal Food and Drug Administration updated the food labeling requirements. Therefore clarifying the information. Overview-Changes-Nutrition-Facts-Label_1</p>
<p>The post <a href="https://www.dssurgery.com/whats-new-with-the-nutrition-facts-label/">What’s New With the Nutrition Facts Label?</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
										<content:encoded><![CDATA[The Federal Food and Drug Administration updated the food labeling requirements. Therefore clarifying the information.

<a href="https://www.dssurgery.com/wp-content/uploads/2020/12/Overview-Changes-Nutrition-Facts-Label_1.pdf" target="_blank" rel="noopener noreferrer">Overview-Changes-Nutrition-Facts-Label_1</a>

<img loading="lazy" decoding="async" class="size-medium wp-image-9677 aligncenter" src="https://www.dssurgery.com/wp-content/uploads/2020/12/Screen-Shot-2020-12-17-at-10.08.54-AM-300x283.png" alt="New Nutrition Label" width="300" height="283" srcset="https://www.dssurgery.com/wp-content/uploads/2020/12/Screen-Shot-2020-12-17-at-10.08.54-AM-300x283.png 300w, https://www.dssurgery.com/wp-content/uploads/2020/12/Screen-Shot-2020-12-17-at-10.08.54-AM-1024x966.png 1024w, https://www.dssurgery.com/wp-content/uploads/2020/12/Screen-Shot-2020-12-17-at-10.08.54-AM-1536x1449.png 1536w, https://www.dssurgery.com/wp-content/uploads/2020/12/Screen-Shot-2020-12-17-at-10.08.54-AM-600x566.png 600w, https://www.dssurgery.com/wp-content/uploads/2020/12/Screen-Shot-2020-12-17-at-10.08.54-AM.png 1652w" sizes="auto, (max-width: 300px) 100vw, 300px" /><p>The post <a href="https://www.dssurgery.com/whats-new-with-the-nutrition-facts-label/">What’s New With the Nutrition Facts Label?</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>Get the Facts on Serving Size</title>
		<link>https://www.dssurgery.com/get-the-facts-on-serving-size/</link>
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		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Tue, 08 Dec 2020 05:57:11 +0000</pubDate>
				<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[post op diet]]></category>
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		<category><![CDATA[nutrition]]></category>
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					<description><![CDATA[<p>Recently the Federal Food and Drug Administration updated the food labeling requirements. Therefore clarifying the information. Serving-Size-New-Nutrition-Facts-Label_0</p>
<p>The post <a href="https://www.dssurgery.com/get-the-facts-on-serving-size/">Get the Facts on Serving Size</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
										<content:encoded><![CDATA[Recently the Federal Food and Drug Administration updated the food labeling requirements. Therefore clarifying the information. <a href="https://www.dssurgery.com/wp-content/uploads/2020/12/Serving-Size-New-Nutrition-Facts-Label_0.pdf">Serving-Size-New-Nutrition-Facts-Label_0</a><p>The post <a href="https://www.dssurgery.com/get-the-facts-on-serving-size/">Get the Facts on Serving Size</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>The New and Improved Nutrition Facts Label – Key Changes</title>
		<link>https://www.dssurgery.com/the-new-and-improved-nutrition-facts-label-key-changes/</link>
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		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Tue, 08 Dec 2020 05:53:38 +0000</pubDate>
				<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[post op diet]]></category>
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		<category><![CDATA[nutrition]]></category>
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					<description><![CDATA[<p>The Federal Food and Drug Administration updated the food labeling requirements. Therefore clarifying the information. Key-Changes-Nutrition-Facts-Label_1_0</p>
<p>The post <a href="https://www.dssurgery.com/the-new-and-improved-nutrition-facts-label-key-changes/">The New and Improved Nutrition Facts Label – Key Changes</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
										<content:encoded><![CDATA[The Federal Food and Drug Administration updated the food labeling requirements. Therefore clarifying the information.

<a href="https://www.dssurgery.com/wp-content/uploads/2020/12/Key-Changes-Nutrition-Facts-Label_1_0.pdf" target="_blank" rel="noopener noreferrer">Key-Changes-Nutrition-Facts-Label_1_0</a><p>The post <a href="https://www.dssurgery.com/the-new-and-improved-nutrition-facts-label-key-changes/">The New and Improved Nutrition Facts Label – Key Changes</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>100% Fruit Juices and Risk of Cancer</title>
		<link>https://www.dssurgery.com/100-fruit-juices-and-risk-of-cancer/</link>
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		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Fri, 17 Apr 2020 04:54:35 +0000</pubDate>
				<category><![CDATA[diabetes]]></category>
		<category><![CDATA[metabolic syndrome]]></category>
		<category><![CDATA[Metabolims]]></category>
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		<category><![CDATA[Splenda]]></category>
		<guid isPermaLink="false">https://www.dssurgery.com/?p=8466</guid>

					<description><![CDATA[<p>The post <a href="https://www.dssurgery.com/100-fruit-juices-and-risk-of-cancer/">100% Fruit Juices and Risk of Cancer</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
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			<p>We have talked about the excess free calorie that is present with fruit juices. Now there is proven research article demonstrating the connection between surgary drinks and the increased risk of cancer. <a href="https://www.dssurgery.com/wp-content/uploads/2020/04/bmjl2408full-1562847559.pdf" target="_blank" rel="noopener noreferrer">This study</a> <a href="https://www.dssurgery.com/wp-content/uploads/2020/04/Screen-Shot-2020-04-12-at-9.41.08-PM.png"><img loading="lazy" decoding="async" class="aligncenter wp-image-8467 size-full" src="https://www.dssurgery.com/wp-content/uploads/2020/04/Screen-Shot-2020-04-12-at-9.41.08-PM.png" alt="" width="725" height="174" srcset="https://www.dssurgery.com/wp-content/uploads/2020/04/Screen-Shot-2020-04-12-at-9.41.08-PM.png 725w, https://www.dssurgery.com/wp-content/uploads/2020/04/Screen-Shot-2020-04-12-at-9.41.08-PM-300x72.png 300w, https://www.dssurgery.com/wp-content/uploads/2020/04/Screen-Shot-2020-04-12-at-9.41.08-PM-600x144.png 600w" sizes="auto, (max-width: 725px) 100vw, 725px" /></a></p>
<p>This study is significant for a number of reasons: It is a very large study with over a 100,000 subjects studied. Furthermore, it was specifically looking for association between nutrition and health.</p>
<p>The conclusion of this research article is self explanatory. Eliminating or cutting down high sugary drinks is an easy way of reducing cancer risk factors. The study also states that there were no identifiable association between the artificial sweeteners and cancer risks. However, this conclusion was not statistically significant. The relationship between sweeteners and cancer have been studied extensively in the past and we&#8217;ve shared several of them.</p>

		</div>
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</div></div></div></div></div><p>The post <a href="https://www.dssurgery.com/100-fruit-juices-and-risk-of-cancer/">100% Fruit Juices and Risk of Cancer</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>Length of Bowel : Hess or No Hess</title>
		<link>https://www.dssurgery.com/length-of-bowel-hess-or-no-hess/</link>
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		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Mon, 23 Mar 2020 01:58:07 +0000</pubDate>
				<category><![CDATA[Duodenal Switch]]></category>
		<category><![CDATA[Nutrition]]></category>
		<category><![CDATA[protein absorption]]></category>
		<category><![CDATA[surgical nutrition]]></category>
		<category><![CDATA[Weight Loss Surgery]]></category>
		<category><![CDATA[Weight loss surgery. duodenal switch]]></category>
		<category><![CDATA[bariatric surgery]]></category>
		<category><![CDATA[BPD]]></category>
		<category><![CDATA[BPD/DS]]></category>
		<category><![CDATA[failed gastric bypass]]></category>
		<category><![CDATA[revisional weight loss surgery]]></category>
		<category><![CDATA[SADI]]></category>
		<category><![CDATA[SIPS]]></category>
		<category><![CDATA[Weight loss surgery]]></category>
		<guid isPermaLink="false">https://www.dssurgery.com/?p=8112</guid>

					<description><![CDATA[<p>The post <a href="https://www.dssurgery.com/length-of-bowel-hess-or-no-hess/">Length of Bowel : Hess or No Hess</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
]]></description>
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			<p>&#8220;&#8230;What is the length of my common channel&#8221; is probably one of the frequently asked questions about the duodenal switch operation in the office. This usually comes up at the initial consult when patients repost credible sources such as Dr. Google and Dr. Facebook for patient with different bowel length have done well or not so after duodenal switch operation. Dr. Hess described the Duodenal Switch by using total bowel length measurements and creating the common channel as a percentage of the total small bowel length.  However, it seems that this is being done less and less.</p>
<p>This leads to my explanation that is on the website</p>
<p>Hess calculator : <a href="https://www.dssurgery.com/duodenal-switch-limb-length/" target="_blank" rel="noopener noreferrer">Bowel Length Calculator</a></p>
<p>How the actual measurements matters: <a href="https://www.dssurgery.com/videos/length-measurement-duodenal-switch/" target="_blank" rel="noopener noreferrer">Bowel length video link</a></p>
<p>In 2019, <a href="https://www.dssurgery.com/wp-content/uploads/2020/03/Correlation_Between_the_Total_Small_Bowel_Length_a.pdf.pdf" target="_blank" rel="noopener noreferrer">Bekheit et.al published a very interesting</a> study comparing total small bowel length (TSBL) to a number of variables such as height, weight, sex and BMI. They identified a few loose correlations. Male patient have longer TBSL than females. There was correlation between TSBL and height stronger in males than females but not statistically significant.</p>
<p>In Conclusion <em><strong>they</strong></em> reported &#8221; Despite statistical significance of the correlation between the TSBL and the height and weight of the included participants, the correlation seems to have no clinical meaning since the effect size is negligible. &#8221;</p>
<p>As I have <a href="https://www.dssurgery.com/standard-common-channel-duodenal-switch-will-result-weight-regain/" target="_blank" rel="noopener noreferrer">previously discussed this </a> Making the common and alimentary length standard for every duodenal switch patient will make some loose too much and other not enough weight.</p>
<p>Figure 1 shows TSBL on the horizontal axis, and height, weight, BMI and Age on the vertical axis. For the most part what they all show is that one can not predict how long a patients bowel is by any of the measures that we take in the office as a part of the routine exam.</p>
<p><a href="https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.04.10-PM.png"><img loading="lazy" decoding="async" class="aligncenter wp-image-8113 size-full" src="https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.04.10-PM.png" alt="" width="1115" height="458" srcset="https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.04.10-PM.png 1115w, https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.04.10-PM-300x123.png 300w, https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.04.10-PM-1024x421.png 1024w, https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.04.10-PM-600x246.png 600w" sizes="auto, (max-width: 1115px) 100vw, 1115px" /></a></p>
<p>This raises, the concerns  that I had raised previously. How could two similar patients who have the same weight, age, sex and BMI have the same surgery and expect the same result if one of them has TSBL of 400 cm and the other one 800cm?</p>
<p><a href="https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.05.52-PM.png"><br />
<img loading="lazy" decoding="async" class="size-full wp-image-8114 aligncenter" src="https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.05.52-PM.png" alt="" width="585" height="304" srcset="https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.05.52-PM.png 585w, https://www.dssurgery.com/wp-content/uploads/2020/03/Screen-Shot-2020-03-07-at-5.05.52-PM-300x156.png 300w" sizes="auto, (max-width: 585px) 100vw, 585px" /></a>If both of the patients get the same &#8220;cookie cutter&#8221; duodenal switch with the same lengths, then the patient with TSBL of 400 will have much longer common channel if the surgeon does not customize the length of the bowel. This is an example of many patients whom we have revised over the years where they had a duodenal switch done with the &#8220;standard&#8221; 125cm common channel and when we measured the total length the patient had 500 cm TSBL.</p>
<p><a href="https://www.dssurgery.com/?s=length+of+bowel">Additional Links here</a>.</p>

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</div></div></div></div></div><p>The post <a href="https://www.dssurgery.com/length-of-bowel-hess-or-no-hess/">Length of Bowel : Hess or No Hess</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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		<title>Protein Intake</title>
		<link>https://www.dssurgery.com/protein-intake/</link>
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		<dc:creator><![CDATA[Dr. Ara Keshishian]]></dc:creator>
		<pubDate>Mon, 14 Oct 2019 15:08:34 +0000</pubDate>
				<category><![CDATA[Duodenal Switch]]></category>
		<category><![CDATA[GRDS]]></category>
		<category><![CDATA[Health]]></category>
		<category><![CDATA[Lap Sleeve Gastretomy]]></category>
		<category><![CDATA[Nutrition]]></category>
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					<description><![CDATA[<p>The post <a href="https://www.dssurgery.com/protein-intake/">Protein Intake</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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			<p><a href="https://www.dssurgery.com/protein/" target="_blank" rel="noopener noreferrer">Protein</a> intake requirements change over time following weight loss surgery. This is based on the requirements imposed on our body by a number of variables. These include, activity level, muscle mass, over all health condition to name a few.</p>
<p>A very young muscular athletic male with a BMI or 30 will require much higher protein intake (and absorption) that an inactive older Female with the same BMI. The same young athletic male will require much higher protein intake is he is recovering from a surgery than his baseline.</p>
<p>As we have stated in the past, the protein intake, should be adequate and not excessive. High level of protein intake that are not accounted  for based on muscle mass and activity level, will eventually result in weight gain. The best measure of protein intake in a stable weight patient over 3-4 years post op  is their albumin and protein level. Following your yearly laboratory values at a minimum is an important part of weight loss surgery follow up care.</p>
<p>You also need to adjust protein intake when necessary. Protein needs increase depending on physical needs, infection, healing, pregnancy, surgery, age, injury, etc. Plastic surgery requires higher protein needs for appropriate healing.</p>
<p>Information on protein sources and quality<a href="https://www.dssurgery.com/protein-sources/" target="_blank" rel="noopener noreferrer"> here.</a></p>
<p>The basic formula for protein intake is 1gm/kg of ideal body weight. The calculator below will provide a guide for the protein into based on your stable weight in lbs.</p>
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</div></div></div></div></div><p>The post <a href="https://www.dssurgery.com/protein-intake/">Protein Intake</a> appeared first on <a href="https://www.dssurgery.com">DSSurgery</a>.</p>
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